Delayed function reduces renal allograft survival independent of acute rejection

Hepatitis C, acute humoral rejection, and renal allograft survival.

The effect of recipient hepatitis C virus (HCV) infection on renal allograft loss and acute rejection in kidney transplantation remains controversial. We studied 354 renal allograft recipients transplanted during 1996 to 2001 who had HCV antibodies (Ab) measured before transplantation. The primary outcome was death-censored allograft loss and the secondary outcome was acute humoral rejection (A...

Soluble CD30 and Acute Renal Allograft Rejection

Acute allograft pancreatitis associated with renal allograft rejection.

Acute allograft pancreatitis is common following simultaneous pancreas and kidney (SPK) transplantation with either bladder or enteric drainage w1,2x. Allograft pancreatitis may be caused by infection, bladder drainage problems, alcohol, drugs and diet w1x. Pancreatic allograft rejection, usually occurring in the context of renal allograft rejection, may cause a syndrome similar to acute allogr...

Mechanisms of Renal Allograft Rejection

Rejection is the major cause of graft failure, and if the injury to the tubules and glomeruli is severe, the kidney may not recover. It is therefore important to diagnose acute rejection as soon as possible to institute prompt antirejection therapy. Generally, the success with which rejection can be reversed by immunosuppressive agents determines the chance of long-term success of the transplan...

Treatment of acute renal allograft rejection with OKT3 monoclonal antibody.

Eight cadaver donor renal allograft recipients, who had received azathioprine and prednisone from the day of transplantation, were treated with OKT3 monoclonal antibody (reactive with all mature peripheral blood T cells) at the time of diagnosis of acute rejection. In all cases, loss of essentially all detectable peripheral blood OKT3-reactive cells was noted within minutes after the initial 1-...